Author

Zoe J. Rutter

University of DundeeORCID 0000-0002-7500-2276Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Alessio CiulliiD· 2 shared Abby M. Thornhill· 1 shared Angus D. CowaniD· 1 shared Benjamin F. CravattiD· 1 shared Bruno N. MelilloiD· 1 shared Bryce da CamaraiD· 1 shared Charlie HattoniD· 1 shared Daniela Vanessa WengeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Alessio CiulliORCID

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2 papers

Recent·Most cited

High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity

James B. Shaum, Miquel Muñoz i Ordoño, Erica A. Steen, Daniela Vanessa Wenge, Hakyung Cheong, Jordan Janowski, Moritz Hunkeler, Eric M. Bilotta, Zoe J. Rutter, Paige A. Barta, Abby M. Thornhill, Natalia Milosevich, Lauren M. Hargis, Timothy R. Bishop, Trever R. Carter, , Michael A. Erb

This study uses high-throughput chemistry to discover chemical inducers of proximity by modifying pre-existing ligands and screening for degrader activity.

Nature Chemical Biology · Feb 16, 2026Peer-reviewedBiochemistry

Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation

Suzanne O’Connor, Zoe J. Rutter, Angus D. Cowan, Markus Zeeb, Florian P. C. Binder, Yuting Cao, Sohini Chakraborti, Stefan Djukic, Leonhard Geist, Elizabeth K. J. Hogg, Giorgia Kidd, Matthias Krumb, Simon Langer, Denis Schmidt, Liam Martin, , Alessio Ciulli

This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.

bioRxiv · Dec 22, 2025 · PreprintBiochemistry