High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
Mathias Mahn, Lihi Gibor, Pritish Patil, Katayun Cohen-Kashi Malina, Shir Oring, Yoav Printz, Rivka Levy, Ilan Lampl, Ofer Yizhar
This paper improves optogenetic silencing by enhancing membrane targeting and subcellular compartmentalization of GtACRs, resulting in more efficient neuronal inhibition.
Nature Communications · Oct 2, 2018Peer-reviewedNeuroscience