Ofer Yizhar

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

This study shows oxytocin signaling in pups affects vocal behavior during maternal separation and reunion, with sex-specific effects when oxytocin neurons are silenced.

This study evaluates eOPN3, a red-shifted inhibitory opsin, in a pig model of Temporal Lobe Epilepsy to modulate seizure activity using optogenetics.

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

The paper identifies factors determining functional synaptic connectivity among mPFC neurons projecting to the basolateral amygdala, showing anatomical and intrinsic properties influence connection probability.

The paper develops a modified model incorporating PV and SOM interneuron subtypes to explore their functional roles in working memory and makes testable predictions.

This paper introduces eOPN3, a modified mosquito rhodopsin that suppresses synaptic transmission with high spatiotemporal precision in vivo.

This paper introduces a novel mouse model of focal cortical seizures using chemogenetic inhibition of GABAergic neurons, showing reliable induction of seizures with characteristics similar to human epilepsy.

This study shows that locus-coeruleus norepinephrine activity determines the likelihood of sensory-evoked awakenings from sleep, with reduced activity during sleep suppressing responses to auditory stimuli.

This study investigates how social information is encoded in the medial prefrontal cortex of mice and shows impaired social representation in Cntnap2 knockout mice, linking prefrontal dynamics to autism-related social dysfunction.

This paper improves optogenetic silencing by enhancing membrane targeting and subcellular compartmentalization of GtACRs, resulting in more efficient neuronal inhibition.

The paper introduces SWIFT, a computational imaging method for capturing coordinated neuronal activity across large tissue volumes in mammals at high speed and resolution.