HIV-producing resting T cells monopolize virus production, associated PANoptosis, and persistence in lymphoid tissue
Lijie Duan, Mark A Sanders, Stephen W. Wietgrefe, Defeng Tian, Peter J. Southern, Jodi L. Anderson, Garritt Wieking, Timothy W. Schacker, Ashley T. Haase
The paper identifies HIV-producing resting T cells as the primary source of virus production in lymphoid tissue germinal centers before ART and shows their role in PANoptosis and persistence during treatment.
bioRxiv · Feb 7, 2026 · PreprintMicrobiology