The native human glomerulus features a slit diaphragmresembling a densely interwoven fishnet
Deborah Moser, Alexandra N. Birtasu, Lilli Skaer, Pauline Roth, Lisa Rehm, Mike Wenzel, Julia Bein, Jens W. Köllermann, Mbuso S. Mantanya, Felix K.‐H. Chun, Margot P. Scheffer, Achilleas S. Frangakis
The paper uses cryo-electron tomography to reveal the native structure of the human slit diaphragm, showing a fishnet-like lattice with 9 nm spacing, more compact than in mice or Drosophila.
JCI Insight · Jan 1, 2026Peer-reviewedPhysiology