Jens W. Köllermann

The paper uses cryo-electron tomography to reveal the native structure of the human slit diaphragm, showing a fishnet-like lattice with 9 nm spacing, more compact than in mice or Drosophila.

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.