A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Eliminates Ex Vivo Reservoirs
Lin-Chun Chang, Michael T. Yin, Gregory M. Laird, Kristen D. Ritter, Jayesh Shah, Asim Kumar Debnath
This paper demonstrates that PZ703b, a dual Bcl-2/Bcl-xL degrader, reverses HIV latency and reduces the replication-competent reservoir in ex vivo CD4+ T cells from ART-suppressed patients.
bioRxiv · Oct 16, 2024 · PreprintMolecular Biology