Parkinson's disease-derived α-Synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Cansu Yildirim, Alexis Fenyi, Pierre Besnault, Lina Gomez, Julia Elisa Sepulveda-Diaz, Patrick Pierre Michel, Ronald Melki, Stéphane Hunot
The paper investigates how Parkinson's disease-derived α-synuclein fibrils combined with inflammatory factors drive a neurotoxic microglial phenotype.
bioRxiv · Nov 30, 2023 · PreprintNeuroscience