Author

Alexis Fenyi

Centre National de la Recherche ScientifiqueORCID 0000-0003-3270-2085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Ronald MelkiiD· 3 shared Bryan A. KillingeriD· 1 shared Cansu Yildirim· 1 shared Domenic BurgeriD· 1 shared Ellen SidranskyiD· 1 shared Gian D. PaliD· 1 shared Henning StahlbergiD· 1 shared Jeffrey H. KordoweriD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Ronald MelkiORCID

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3 papers

Recent·Most cited

Neurosciencenpj Parkinson s DiseasePeer-reviewedMay 21, 2024

Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.

Sara Walton, Alexis Fenyi, Tyler Tittle…·Jeffrey H. Kordower

The study tests whether GBA1 mutations or mouse genotype affect alpha-synuclein seeding in mice, finding no significant influence on seeding efficacy or pathology spread.

5 citations

mouseproteomics

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NeurosciencebioRxivPreprintNov 30, 2023

Parkinson's disease-derived α-Synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype

Cansu Yildirim, Alexis Fenyi, Pierre Besnault…·Stéphane Hunot

The paper investigates how Parkinson's disease-derived α-synuclein fibrils combined with inflammatory factors drive a neurotoxic microglial phenotype.

1 citation

humanproteomics

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NeurosciencebioRxivPreprintJul 8, 2021

Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains

Domenic Burger, Alexis Fenyi, Luc Bousset…·Ronald Melki

Three fibril polymorphs, amplified from Parkinson's and multiple system atrophy brain homogenate by PMCA, adopt folds unlike any published alpha-synuclein arrangement; their disease relevance is untested.

43 citations

humanexperimental assay

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