Mutations in the juxtamembrane segment of the cholesterol-binding site of APP alter its processing and promotes production of shorter, less toxic Aβ peptides.
Linda Hanbouch, Béatrice Schaack, Amal Kasri, Gaëlle Fontaine, Eleni Gkanatsiou, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Gilles Mourier, Nicolas Gilles, Mark John Millan, Catherine Marquer, Henrik Zetterberg, Lydie Boussicault, Marie‐Claude Potier
This study shows that mutations in the juxtamembrane cholesterol-binding site of APP reduce production of toxic Aβ40 and Aβ42 peptides and increase shorter, less toxic Aβ peptides.
bioRxiv · Nov 16, 2020 · PreprintNeuroscience