Author

Amal Kasri

Allen Institute for Brain ScienceORCID 0000-0002-9656-4710Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Gunnar BrinkmalmiD· 2 shared Henrik ZetterbergiD· 2 shared Marie‐Claude PotieriD· 2 shared Béatrice SchaackiD· 1 shared Catherine MarqueriD· 1 shared Diana PiotrowskaiD· 1 shared Elena CamporesiiD· 1 shared Eleni GkanatsiouiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Gunnar BrinkmalmORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction

Louis Valay, Amal Kasri, Vincent Fontaine, Elena Camporesi, Stéphanie Bigou, Gunnar Brinkmalm, Diana Piotrowska, Laury Dancette, Manon Lamontagne, François‐Xavier Lejeune, Pinku Halder, Philippe Ravassard, Martin Irmler, Henrik Zetterberg, Johannes Beckers, Marie‐Claude Potier

bioRxiv · Oct 30, 2026 · PreprintNeuroscience

Mutations in the juxtamembrane segment of the cholesterol-binding site of APP alter its processing and promotes production of shorter, less toxic Aβ peptides.

Linda Hanbouch, Béatrice Schaack, Amal Kasri, Gaëlle Fontaine, Eleni Gkanatsiou, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Gilles Mourier, Nicolas Gilles, Mark John Millan, Catherine Marquer, Henrik Zetterberg, Lydie Boussicault, Marie‐Claude Potier

This study shows that mutations in the juxtamembrane cholesterol-binding site of APP reduce production of toxic Aβ40 and Aβ42 peptides and increase shorter, less toxic Aβ peptides.

bioRxiv · Nov 16, 2020 · PreprintNeuroscience