Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence
Nadine Taudte, Linda Liebe, Nadine Jänckel, Daniel Ramsbeck, Stephan Schilling, Jan Potempa, Sigrun Eick, Mirko Buchholz
This study identifies S-0636, a small molecule inhibitor of PgQC, which reduces Porphyromonas gingivalis virulence without killing the bacteria or causing resistance.
Frontiers in Oral Health · Mar 13, 2026Peer-reviewedMicrobiology