Jan Potempa

A moonlighting serpin of Tannerella forsythia compromises the bactericidal activity of neutrophils

This study identifies miropin, a prokaryotic serpin from Tannerella forsythia, which suppresses neutrophil antimicrobial activity by inhibiting serine proteases and myeloperoxidase, promoting bacterial survival in vivo.

Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence

This study identifies S-0636, a small molecule inhibitor of PgQC, which reduces Porphyromonas gingivalis virulence without killing the bacteria or causing resistance.

Effect of a bacterial Glutaminyl Cyclase inhibitor on multi-species-biofilms

This study evaluates a bacterial Glutaminyl Cyclase inhibitor's effect on multispecies biofilms, showing reduced metabolic activity and virulence factors without affecting bacterial counts.

Periodontopathogens interfere with the human renin-angiotensin system through a surface-attached protease

This study shows that oral pathogens Porphyromonas gingivalis and Tannerella forsythia use surface-attached proteases to alter the renin-angiotensin system by generating Ang 1-7.

Chryseobacterium indologenes mediates resistance to osimertinib by activating the IGF1R pathway in EGFR-mutant lung adenocarcinoma

Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen

This study shows that tyrosine phosphorylation regulates the coupling between one carbon metabolism and virulence in Porphyromonas gingivalis by controlling gingipain protease localization and activity.

Innocent until proven guilty: Tannerella forsythia may attenuate the virulence of Porphyromonas gingivalis

This study shows that Tannerella forsythia's miropin inhibits Porphyromonas gingivalis proteases, reducing its virulence and challenging Tf's role as a pathogen.

Infection-Specific Reprogramming of Microglia Reveals Distinct Virulence Pathways Linking Periodontal Pathogens to Alzheimer's Disease

This study identifies pathogen-specific microglial reprogramming by periodontal pathogens, linking virulence factors to Alzheimer's disease neuroinflammation.

Virion stripping: A new role for bacterial proteases

This paper shows that Porphyromonas gingivalis proteases reduce viral load and modulate host interferon responses during RSV infection.

Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights

This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.