Focal adhesion pathway inhibition is the central axis of macrophage phenotypic responses to monoclonal antibody therapy in aggressive lymphoma via high-throughput screening and high-content imaging
Stuart James Blakemore, Peter Zentis, Linda Müller, Reinhild Brinker, Michael Michalik, Christian Jüngst, Anna C. Beielstein, Jing Zhang, René Neuhaus, Alexandra Florin, Michael J. Hallek, Jörn Meinel, Reinhard Buettner, Astrid C Schauss, Christian Philipp Pallasch
This study identifies focal adhesion pathway inhibition as a key mechanism enhancing macrophage phagocytosis and improving anti-CD20 monoclonal antibody therapy in aggressive lymphoma through high-throughput screening and high-content imaging.
bioRxiv · Sep 23, 2025 · PreprintCell Biology