Taxonomy-free fecal microbiome profiles enable robust prediction of immunotherapy response and toxicity in melanoma
Anastasia Lucas, McKenna Reale, Yuri I. Wolf, Bryant Duong, Yichi Zhang, Jayamanna M. Wickramasinghe, Lindsey Behlman, Steven M. Jones, Stephanie Higgins, Ahmed M. Moustafa, Abdurrahman Elbasir, Ravi K. Amaravadi, Tara C. Mitchell, Alexander Chan Chi Huang, Noam Auslander
This study identifies microbiome-derived protein biomarkers for predicting immunotherapy response and toxicity in melanoma without relying on taxonomic classification.
bioRxiv · Nov 6, 2025 · PreprintCancer Biology