Author

McKenna Reale

The Wistar Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Noam AuslanderiD· 3 shared Abdurrahman ElbasiriD· 1 shared Ahmed M. MoustafaiD· 1 shared Alexander Chan Chi HuangiD· 1 shared Anastasia Lucas· 1 shared Andrew PattersoniD· 1 shared Andrew V. KossenkoviD· 1 shared Arjun RajiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

Noam AuslanderORCID

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Author profile →

3 papers

Recent·Most cited

Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance

Haiyin Li, Yeqing Chen, Jessica Kaster, Maggie Dunne, Min Xiao, Ling Li, Monzy Thomas, Nazifa Promi, Dylan F. Fingerman, Gregory Schuyler Brown, Qiuxian Zheng, Xingyue Zhu, McKenna Reale, Andrew Patterson, Le Gao, , Meenhard Herlyn

This study identifies drug-tolerant persister states in melanoma using MeRLin, showing their role in resistance and tumor recurrence.

Molecular Cancer · Mar 3, 2026Peer-reviewedCancer Biology

A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis

Behzad Mansoori, Ying Song, Tian Zhang, Zihan Zheng, Qing Zhu, Shun Li, Mckenna Reale, Christian Pangilinan, Janvhi Suresh Machhar, Jinghui Liang, Jason Chang, Young-Kwon Hong, Gerald B. Wertheim, Maureen E. Murphy, Yong-Mi Kim, , Chengyu Liang

This study identifies UVRAG as a negative regulator of NOTCH1 by promoting K27-linked ubiquitination and lysosomal degradation, revealing a checkpoint to prevent excessive NOTCH signaling.

bioRxiv · Dec 19, 2025 · PreprintMolecular Biology

Taxonomy-free fecal microbiome profiles enable robust prediction of immunotherapy response and toxicity in melanoma

Anastasia Lucas, McKenna Reale, Yuri I. Wolf, Bryant Duong, Yichi Zhang, Jayamanna M. Wickramasinghe, Lindsey Behlman, Steven M. Jones, Stephanie Higgins, Ahmed M. Moustafa, Abdurrahman Elbasir, Ravi K. Amaravadi, Tara C. Mitchell, Alexander Chan Chi Huang, Noam Auslander

This study identifies microbiome-derived protein biomarkers for predicting immunotherapy response and toxicity in melanoma without relying on taxonomic classification.

bioRxiv · Nov 6, 2025 · PreprintCancer Biology