FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer
Yanchun Zhang, Xuexue Xiong, Qi Zhu, Jiali Zhang, Shengmiao Chen, Yuetong Wang, Jian Cao, Li Chen, Linjun Hou, Xi Zhao, Piliang Hao, Jian Chen, Min Zhuang, Dake Li, Gaofeng Fan
The paper identifies FER-mediated tyrosine phosphorylation of IRS4 and its role in activating the PI3K-AKT pathway, contributing to ovarian cancer tumorigenesis.
eLife · Apr 26, 2022Peer-reviewedMolecular Biology