The paper identifies increased fucosylation patterns in saliva glycoproteins of lung cancer patients, suggesting potential for early diagnosis of lung adenocarcinoma.

ACS Omega · May 19, 2022Peer-reviewedSystems Biology

FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer

Yanchun Zhang, Xuexue Xiong, Qi Zhu, Jiali Zhang, Shengmiao Chen, Yuetong Wang, Jian Cao, Li Chen, Linjun Hou, Xi Zhao, Piliang Hao, Jian Chen, Min Zhuang, Dake Li, Gaofeng Fan

The paper identifies FER-mediated tyrosine phosphorylation of IRS4 and its role in activating the PI3K-AKT pathway, contributing to ovarian cancer tumorigenesis.

eLife · Apr 26, 2022Peer-reviewedMolecular Biology

Essential role for Ggct in erythrocyte antioxidant defense

Zaoke He, Xiaoqin Sun, Shixiang Wang, Dongsheng Bai, Xiangyu Zhao, Ying Han, Piliang Hao, Xuesong Liu

This study shows that Ggct deletion in mice causes splenomegaly and anemia due to oxidative damage and reduced glutathione in red blood cells.

bioRxiv · Jun 21, 2021 · PreprintGenetics