Translational control of microglial inflammatory and neurodegenerative responses
Sara Bermudez, Jung‐Hyun Choi, Jacob W. Vogel, Sung‐Hoon Kim, Niaz Mahmood, Vivian Yuchan Zhu, Danielle Cozachenco, Moein Yaqubi, Linqiao Zhou, Jo Anne Stratton, Oskar Hansson, Luke M. Healy, Argel Aguilar‐Valles, Nahum Sonenberg
This study identifies the mTORC1-4E-BP1 axis as a neuroprotective mechanism in microglia under AD conditions, showing its role in suppressing inflammation and neurodegeneration.
bioRxiv · Apr 6, 2024 · PreprintNeuroscience