Jo Anne Stratton

This review synthesizes findings on peripheral immune cell changes in Parkinson's disease, identifying common immune signatures and methodological inconsistencies across studies.

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

The paper develops a Ca2+ imaging pipeline to analyze spinal cord activity in pain models, identifying a glial-driven signature in post-traumatic osteoarthritis.

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

This study shows that PINK1 in myeloid cells represses mtDNA release and immune signaling, which contributes to neuronal pathology in Parkinson's disease models.

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

This study shows that the LRRK2 G2019S mutation enhances neutrophil effector functions and drives intestinal inflammation in a mouse model of infectious colitis.

This study investigates ependymal cilia dysfunction in multiple sclerosis, finding dysregulated ciliary genes and impaired ciliary function in MS patients and animal models.

This study uses scRNA-seq to show that DMD satellite cells have molecular impairments and altered differentiation trajectories, leading to reduced regenerative capacity, with autophagy induction potentially rescuing differentiation.

This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.

The paper identifies Myocilin as a marker for glia limitans superficialis astrocytes in mouse and human, showing their specialized morphology and evolutionary conservation.

The paper identifies shared molecular mechanisms between Alzheimer's and Parkinson's disease by analyzing gene co-expression at sub-cell-type resolution using single-nucleus datasets.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

This study finds that patients with primary ciliary dyskinesia show increased ventriculomegaly and age-related ventricular enlargement, potentially linked to ependymal ciliary dysfunction.

The paper uses multiomic single nucleus RNA/ATAC sequencing to show ependymal cell dysregulation correlates with periventricular pathology in MS and identifies IFNγ as a driver.

This study shows that a single Citrobacter rodentium infection increases blood-brain barrier permeability and triggers neuroinflammation in Pink1 knockout mice without dopamine neuron loss.

The paper identifies four subpopulations of human choroid plexus epithelial cells, including TYRP1-high cells with distinct molecular features related to pigmentation, cell cycling, and stress.

This study creates the first layer-resolved atlas of the adult human meninges using single-cell RNA sequencing, MERFISH, and immunolabeling, identifying 10 fibroblast subpopulations and novel interactions in the dura and subarachnoid space.

This study shows that senolytic treatment reduces microglia and alleviates EAE symptoms in mice, suggesting senescent glia contribute to neuroinflammation.

This study identifies the mTORC1-4E-BP1 axis as a neuroprotective mechanism in microglia under AD conditions, showing its role in suppressing inflammation and neurodegeneration.

This study characterizes dopaminergic neurons in the gut using a DAT-cre reporter mouse line, revealing distinct subtypes with dual-transmitter content.

This study shows that mitochondrial antigen-specific CD8+ T cells can induce nigrostriatal dysfunction and dopamine neuron degeneration in mice, supporting an immune-driven mechanism in Parkinson's disease.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

The paper optimizes an iMGL protocol to generate microglia-like cells from an ALSP patient, revealing functional defects in migration and phagocytosis.

The paper shows that combining α-synuclein fibrils with immune challenges causes Lewy body-like inclusions in human dopaminergic neurons, while cortical neurons do not form such inclusions.

This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.