Author

Argel Aguilar‐Valles

Carleton UniversityORCID 0000-0002-2272-1138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1

Frequent Co-Authors

Danielle CozachencoiD· 3 shared Nahum SonenbergiD· 3 shared Brandon RodrigueiD· 2 shared Felipe Campos RibeiroiD· 2 shared Fernanda G. De FeliceiD· 2 shared Jean‐Claude LacailleiD· 2 shared Karim NaderiD· 2 shared Mychael V. LourencoiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersNeuroscience

Danielle CozachencoORCID

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Author profile →

4 papers

Recent·Most cited

Psilocybin as a Treatment for Repetitive Mild Head Injury: Evidence from Neuroradiology and Molecular Biology

Eric K. Brengel, Bryce Axe, Ashwath Maheswari, Muhammad I. Abeer, Richard J. Ortiz, Taylor J. Woodward, Reagan Walhof, Wenwen Du, Rachel Utama, Brandon Rodrigue, Noah J. Cavallaro, Anna Brettler, Courtney Sawada, Anna Moore, Shreyas Balaji, , Craig F. Ferris

This study investigates psilocybin's effects on repetitive mild head injury in rats, showing reductions in edema, improved vascular function, and modulation of neuroinflammatory and neuroplasticity markers.

Communications Biology · Sep 8, 2026Peer-reviewedNeuroscience

Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer's disease

Felipe Campos Ribeiro, Danielle Cozachenco, Michael Parkhill, Brandon Rodrigue, Caio Borges, Jean‐Claude Lacaille, Karim Nader, Fernanda G. De Felice, Mychael V. Lourenco, Argel Aguilar‐Valles, Nahum Sonenberg, Sergio Teixeira Ferreira

This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.

Aging Cell · Dec 3, 2025Peer-reviewedNeuroscience

The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease

Felipe Campos Ribeiro, Danielle Cozachenco, Elentina K. Argyrousi, Agnieszka Staniszewski, Shane A. Wiebe, Joao D. Calixtro, Rubens L Soares‐Neto, Aycheh Al‐Chami, Fatema El Sayegh, Sara Bermudez, Emily Arsenault, Marcelo Cossenza, Jean‐Claude Lacaille, Karim Nader, Hongyu Sun, , Sergio Teixeira Ferreira

Alzheimer s & Dementia · Jun 27, 2024Peer-reviewedNeuroscience

Translational control of microglial inflammatory and neurodegenerative responses

Sara Bermudez, Jung‐Hyun Choi, Jacob W. Vogel, Sung‐Hoon Kim, Niaz Mahmood, Vivian Yuchan Zhu, Danielle Cozachenco, Moein Yaqubi, Linqiao Zhou, Jo Anne Stratton, Oskar Hansson, Luke M. Healy, Argel Aguilar‐Valles, Nahum Sonenberg

This study identifies the mTORC1-4E-BP1 axis as a neuroprotective mechanism in microglia under AD conditions, showing its role in suppressing inflammation and neurodegeneration.

bioRxiv · Apr 6, 2024 · PreprintNeuroscience