Sensitizing Immune-Refractory Ovarian Tumors via p53 Mutation-Tailored Immunotherapy
Rishita Chatterjee, Arturo Simoni Nieves, An Nhien Truong, Moshit Lindzen, Furkan Ozmen, Christopher Cherry, Pascale Zwicky, Saptaparna Mukherjee, Boobash-Raj Selvadurai, Tomer Meir Salame, Nitin Gupta, Suvendu Giri, Lior Kramarski, Yahel Avraham, Eviatar Weizman, , Yosef Yarden
This study identifies a p53 mutation-specific immunotherapy strategy for ovarian cancer by targeting AREG and PD-L1, showing efficacy in mouse models and patient-derived organoids.
bioRxiv · Jun 23, 2025 · PreprintCancer Biology