Christopher Cherry

Age and sex alter the immune response in a chronic fibrosis model via changes in T cell and macrophage phenotype

This study shows age and sex affect fibrosis and immune response in a mouse model of implant-induced chronic inflammation through changes in T cell and macrophage phenotypes.

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation

This study identifies molecular and immune mechanisms driving malignant transformation from inverted papilloma to sinonasal squamous cell carcinoma using multi-omics analyses.

γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal

The paper introduces dominoSignal, a software tool that statistically tests differential cell signaling from single-cell data to infer changes in cell-cell communication networks.

Tissue Injury and Biomaterial Treatment Modulate Tumor Growth and Response to Immunotherapy

This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.

Immune checkpoint inhibitors amplify type 2 immune mediated repair bypro-regenerative scaffolds

This study shows immune checkpoint inhibitors enhance type 2 immunity and regeneration in ECM-treated wounds by promoting Treg/TH2 plasticity and pro-regenerative macrophages.

Sensitizing Immune-Refractory Ovarian Tumors via p53 Mutation-Tailored Immunotherapy

This study identifies a p53 mutation-specific immunotherapy strategy for ovarian cancer by targeting AREG and PD-L1, showing efficacy in mouse models and patient-derived organoids.

Antibiotic-induced microbiota depletion impairs the pro-regenerative response to a biological scaffold in mice

This study shows antibiotic-induced microbiota depletion in mice impairs the pro-regenerative immune response to a biological scaffold, reducing myocyte regeneration and increasing fibrosis.

Single-cell transcriptomics reveal diverging pathobiology and opportunities for precision targeting in scleroderma-associated versus idiopathic pulmonary arterial hypertension

This study uses single-cell RNA sequencing to compare scleroderma-associated and idiopathic pulmonary arterial hypertension, identifying distinct pathobiological features and potential drug targets.

Intercellular signaling dynamics from a single cell atlas of the biomaterials response

The paper creates a single cell atlas of biomaterials response using scRNA-seq and develops a tool to analyze intercellular signaling patterns in the context of biomaterials.