Legumain (asparaginyl endopeptidase) modulates extracellular matrix dynamics in pulmonary fibrosis
Baptiste Rigoux, Alexis David, Damien Sizaret, Rania Allouche, Clementine LEBOUCHE, Lise Vanderlynden, Fabien Lecaille, Marcin Poręba, Florian Veillard, Sylvain Marchand-Adam, Gilles Lalmanach, Ahlame Saidi
This study identifies legumain and cathepsin V as key regulators of extracellular matrix remodeling in pulmonary fibrosis, acting together with cystatin M/E to modulate fibronectin and elastin turnover.
bioRxiv · Jul 21, 2026 · PreprintBiochemistry