Multi-PGS enhances polygenic prediction: weighting 937 polygenic scores
Clara Albiñana, Zhihong Zhu, Andrew Joseph Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia Marie Bulik, Liselotte V Pedersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, DAVID MICHAEL HOUGAARD, Thomas Mears Werge, Anders Dupont Børglum, Preben Bo Mortensen, , Bjarni Jóhann Vilhjálmsson
This paper introduces a framework to enhance polygenic prediction by combining multiple polygenic scores, showing significant accuracy improvements for psychiatric disorders and other traits.
medRxiv · Sep 14, 2022 · PreprintGenetic & Genomic Medicine