Clara Albiñana

Population-scale molecular reconstruction of human circadian phase from blood biomarkers

The paper infers circadian phase from blood biomarkers in UK Biobank using machine learning and defines a new construct, circadian acceleration, with genetic and environmental associations.

As rates of ASD and ADHD rise, genetic contributions fall: Evidence for widening diagnostic criteria

This study shows that as ASD and ADHD diagnoses have increased, the genetic risk associated with these conditions has decreased over time.

Polygenic risk score prediction accuracy convergence

This study assesses the progress and limitations of polygenic risk score prediction accuracy for common diseases, showing diminishing returns from recent GWAS and highlighting the need for broader variant coverage.

Descriptives and genetic correlates of eating disorder diagnostic transitions and presumed remission in the Danish registry.

The paper examines diagnostic transitions and remission in eating disorders using polygenic scores in a Danish cohort, finding significant genetic associations with these outcomes.

The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

This study examines the genetic and phenotypic links between neonatal C3 and C4 protein concentrations and psychiatric and autoimmune disorders, finding no strong causal associations with mental disorders but evidence of lower autoimmune risk with higher C4 levels.

Inferring disease architecture and predictive ability with LDpred2-auto

This paper validates LDpred2-auto for inferring genetic parameters and shows improved heritability capture and predictive performance with an expanded variant set.

Mendelian randomization study of birth weight and risk of psychiatric disorders later in life

This study investigates whether birth weight has a direct causal effect on psychiatric disorders later in life using Mendelian randomization, finding no direct causal relationship.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots

This study identifies genetic loci associated with vitamin D-binding protein and 25 hydroxyvitamin D in neonates and links DBP to vitamin D status and disease risk.

Multi-PGS enhances polygenic prediction: weighting 937 polygenic scores

This paper introduces a framework to enhance polygenic prediction by combining multiple polygenic scores, showing significant accuracy improvements for psychiatric disorders and other traits.

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

This study identifies seven new genetic loci associated with febrile seizures, linking them to fever response and neuronal excitability genes, and suggests potential clinical applications of polygenic risk scores.

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

This study compares methods for combining GWAS summary statistics and individual-level data to improve polygenic prediction, finding that Meta-PRS is often more accurate than Meta-GWAS.