Anders Dupont Børglum

The paper identifies a mid-gestational molecular mechanism linking cortical size and ADHD through genetic and single-cell RNA sequencing analyses.

The paper introduces an adversarial neural network to identify genetic resilience markers in Alzheimer's disease, finding five SNPs associated with resilience independent of polygenic risk scores.

This paper conducts a multi-ancestry GWAS of stimulant use disorder, identifies 19 genome-wide significant loci, and finds genetic correlations with other psychiatric and substance use disorders.

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study shows BRD1 haploinsufficiency disrupts early neuronal programming and synaptic maturation in human induced glutamatergic neurons, leading to altered neurodevelopmental trajectories and increased neuronal activity.

This study shows that as ASD and ADHD diagnoses have increased, the genetic risk associated with these conditions has decreased over time.

This study shows that reduced BRD1 function in minipigs leads to coordinated neurodevelopmental and metabolic changes in both brain and peripheral tissues.

This study identifies synergistic sets of genetic risk variants in psychiatric disorders, suggesting subtypes and reinterpreting shared genetic effects.

The paper identifies chr22q as a regulatory hub where genetic risk for neuropsychiatric conditions is associated with coordinated gene expression downregulation in brain tissue.

This study performs a GWAS on functional brain network metrics and finds genetic overlap with brain structure and autism.

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

The paper identifies five genomic factors explaining most genetic variance across 14 psychiatric disorders and finds shared and disorder-specific genetic signals with distinct biological functions.

This study examines how rare copy number variants and polygenic scores jointly affect psychiatric disorder risk in a large population sample, finding no significant interaction between the two factors.

The paper identifies psychometric archetypes in young adults that correlate with biological markers of mental health vulnerability and resilience, improving predictive models for clinical outcomes.

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

This study conducts a large-scale GWAS of OCD, identifying 15 new genome-wide significant loci and linking OCD to multiple cortical regions and cell types.

This paper identifies shared genetic risk loci between ADHD, cannabis use disorder, and cannabis use, and predicts cannabis use disorder risk in ADHD using polygenic scores.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

This study examines the genetic and phenotypic links between neonatal C3 and C4 protein concentrations and psychiatric and autoimmune disorders, finding no strong causal associations with mental disorders but evidence of lower autoimmune risk with higher C4 levels.

This study investigates whether birth weight has a direct causal effect on psychiatric disorders later in life using Mendelian randomization, finding no direct causal relationship.

ADuLT is a time-to-event GWAS method that outperforms Cox regression in strongly ascertained studies, finding more genome-wide significant associations in psychiatric disorder analyses.

The paper estimates population-based risks of psychiatric disorders associated with 34 recurrent CNVs using a large case-cohort sample, finding moderate risks for ADHD, autism, and schizophrenia, but not depression.

This study identifies 64 new risk loci for major depression, refines its genetic architecture, and shows strong genetic overlap with other psychiatric disorders and educational attainment.

This study examines genetic liability for psychiatric disorders using disorder-specific and transdiagnostic frameworks, finding that depression PRS is associated with multiple disorders and uncovering four functional domains aligning with RDoC.

This study identifies genetic loci associated with vitamin D-binding protein and 25 hydroxyvitamin D in neonates and links DBP to vitamin D status and disease risk.

The paper evaluates how haplotype estimation and whole genome imputation accuracy vary with data integration protocols and phasing methods in a large psychiatric biobank dataset.

This study identifies genetic overlaps between psychiatric disorders, language ability, and creativity through a GWAS of school grades.

This study investigates genetic variants in hydrocephalus patients and finds associations with ciliopathies and autism spectrum disorder using the iPSYCH cohort.

The paper maps the odds ratio for autism associated with rare LoF variants in autism-associated genes and shows sub-diagnostic effects in undiagnosed individuals.