Cynthia Marie Bulik

Suicidality phenotypes reflect both shared and distinct genetic factors

This study identifies shared and distinct genetic factors underlying suicidality phenotypes using GWAS and structural equation modelling.

Genome-Wide Association Study of Distressing Premenstrual Symptoms in Two Nordic Populations

This paper conducts a GWAS of distressing premenstrual symptoms (DPS) in two Nordic populations, identifying a SNP associated with DPS and genetic correlations to psychiatric disorders.

Polygenicity at the pathway level for anorexia nervosa

This study identifies pathway-level polygenicity in anorexia nervosa by constructing pathway-based polygenic risk scores and finding 497 associated pathways.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

Descriptives and genetic correlates of eating disorder diagnostic transitions and presumed remission in the Danish registry.

The paper examines diagnostic transitions and remission in eating disorders using polygenic scores in a Danish cohort, finding significant genetic associations with these outcomes.

Genome-wide association study identifies new loci associated with OCD

This study conducts a large-scale GWAS of OCD, identifying 15 new genome-wide significant loci and linking OCD to multiple cortical regions and cell types.

The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

This study examines the genetic and phenotypic links between neonatal C3 and C4 protein concentrations and psychiatric and autoimmune disorders, finding no strong causal associations with mental disorders but evidence of lower autoimmune risk with higher C4 levels.

Mendelian randomization study of birth weight and risk of psychiatric disorders later in life

This study investigates whether birth weight has a direct causal effect on psychiatric disorders later in life using Mendelian randomization, finding no direct causal relationship.

Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots

This study identifies genetic loci associated with vitamin D-binding protein and 25 hydroxyvitamin D in neonates and links DBP to vitamin D status and disease risk.

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

This study identifies genetic overlaps between psychiatric disorders, language ability, and creativity through a GWAS of school grades.

Multi-PGS enhances polygenic prediction: weighting 937 polygenic scores

This paper introduces a framework to enhance polygenic prediction by combining multiple polygenic scores, showing significant accuracy improvements for psychiatric disorders and other traits.

Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

Exploring the clinical consequences and genetic aetiology of adult weight trajectories

This study examines the genetic and clinical associations of adult weight trajectories using EHR data, identifying disease links and genetic risk factors for weight patterns.

The impact of anorexia nervosa and BMI polygenic risk on childhood growth: a 20-year longitudinal population-based study

This study examines the association between polygenic scores for anorexia nervosa and BMI with growth trajectories over 20 years in children, finding sex-specific effects and potential risk interactions.

The Phenome-wide Consequences of Anorexia Nervosa Genes

This study uses transcriptomic imputation to translate AN GWAS findings into gene expression associations, revealing 47 genes linked to AN and their clinical consequences in a biobank cohort.

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores

The paper investigates genetic associations between eating disorder symptoms and polygenic scores for psychiatric, metabolic, and anthropometric traits in adolescents.

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

This study compares methods for combining GWAS summary statistics and individual-level data to improve polygenic prediction, finding that Meta-PRS is often more accurate than Meta-GWAS.

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

The paper examines sex-differentiated genetic effects across neuropsychiatric and behavioral traits using GWAS summary statistics and finds small, polygenic sex differences with enriched neuron-related genes.

Polygenic prediction of school performance in children with and without psychiatric disorders

The paper examines how a polygenic score for educational attainment predicts school performance in children with and without psychiatric disorders, finding reduced predictive power in ADHD but not ASD.

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

Polygenic score for body mass index is associated with disordered eating in a general population cohort

The paper investigates the association between BMI polygenic scores and disordered eating behaviors in a general population cohort, finding a positive link mediated by BMI.

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

Cross-disorder meta-analysis of eight psychiatric GWAS (232,964 cases, 494,162 controls) reports 109 loci shared by two or more disorders and three groups of correlated disorders.

The Anorexia Nervosa Genetics Initiative: Overview and Methods

The paper describes the methods and recruitment strategies of the Anorexia Nervosa Genetics Initiative (ANGI), which successfully enrolled 13,364 individuals with AN and controls for genetic research.

Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder

This study investigates the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder using a cross-disorder GWAS, finding a significant genetic correlation and associations with psychiatric and metabolic traits.

Psychiatric Genomics: An Update and an Agenda

The paper updates the Psychiatric Genomics Consortium's progress and outlines future goals for translating genetic findings into clinical and therapeutic applications.

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

This paper reports the first genome-wide significant locus for anorexia nervosa and identifies genetic correlations with psychiatric and metabolic traits.