Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer
Yue Zhang, Hanbing Wang, Yutao Wei, Yunfeng Pan, Xueru Song, Jie Shao, Lixia Yu, Tao Shi, Yue Wang
This paper shows that blocking SHP2 enhances FGFR2 inhibitor effectiveness and overcomes resistance in FGFR2-amplified gastric cancer by inhibiting feedback pathways and boosting T cell immunity.
eLife · Mar 23, 2026Peer-reviewedCancer Biology