Author

Lixian Zhou

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ani SolankiiD· 1 shared Benjamin Jung FairiD· 1 shared Bo LiuiD· 1 shared Connor J. KennyiD· 1 shared James A. MastrianniiD· 1 shared Jingxin WangiD· 1 shared Junxing ZhaoiD· 1 shared Qingyao KongiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ani SolankiORCID

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1 paper

Recent·Most cited

Depleting prion protein using splice-switching small molecules

Bo Liu, Benjamin Jung Fair, Zhiling Kuang, Zhichao Tang, Junxing Zhao, Lixian Zhou, Qingyao Kong, Ani Solanki, Connor J. Kenny, James A. Mastrianni, Rui Zhao, Yang Li, Jingxin Wang

This study develops a small-molecule approach to reduce prion protein by modulating pre-mRNA splicing, achieving ~70% PrP reduction in cells and demonstrating synergistic effects with a Luc7L activator in mice.

bioRxiv · Jun 27, 2026 · PreprintBiochemistry