Jingxin Wang

This paper develops PMO-based RNA-degrading chimeras that target SNCA mRNA to reduce α-synuclein levels and prevent pathological aggregation in vitro and in vivo.

This study develops a small-molecule approach to reduce prion protein by modulating pre-mRNA splicing, achieving ~70% PrP reduction in cells and demonstrating synergistic effects with a Luc7L activator in mice.

This study identifies coumarin derivatives that selectively bind RNA single G bulges, revealing key structural features and using computational and experimental methods to guide rational ligand design.

This paper identifies rapaglutin E as a specific inhibitor of GLUT1 and explores its binding mechanism compared to rapaglutin A.

The paper identifies stable RNA secondary structures across organisms using chemical probing data and introduces a database for these structures.

This study identifies TMEM63B as a mammalian thirst receptor in the subfornical organ, showing it mediates osmotic and dehydration-induced thirst through ion channel activity.

The paper estimates the impact of alternative splicing coupled with nonsense-mediated decay on gene expression levels using population-scale genomic data and perturbation experiments.