BiochemistrybioRxivPreprint
Depleting prion protein using splice-switching small molecules
Bo Liu, Benjamin Jung Fair, Zhiling Kuang…·Jingxin Wang
This study develops a small-molecule approach to reduce prion protein by modulating pre-mRNA splicing, achieving ~70% PrP reduction in cells and demonstrating synergistic effects with a Luc7L activator in mice.
DOI 10.64898/2026.06.26.734742