Author

James A. Mastrianni

University of ChicagoORCID 0000-0002-4708-7700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ani SolankiiD· 1 shared Benjamin Jung FairiD· 1 shared Bo LiuiD· 1 shared Connor J. KennyiD· 1 shared Jingxin WangiD· 1 shared Junxing ZhaoiD· 1 shared Lixian Zhou· 1 shared Qingyao KongiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ani SolankiORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintJun 27, 2026

Depleting prion protein using splice-switching small molecules

Bo Liu, Benjamin Jung Fair, Zhiling Kuang…·Jingxin Wang

This study develops a small-molecule approach to reduce prion protein by modulating pre-mRNA splicing, achieving ~70% PrP reduction in cells and demonstrating synergistic effects with a Luc7L activator in mice.

DOI 10.64898/2026.06.26.734742

mousebulk RNA-seq

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