SHP2-triggered endothelium activation fuels estradiol-independent endometrial sterile inflammation
Jie Pan, Lixin Zhao, Wen Fang, Jiao Qu, Linhui Zhai, Minjia Tan, Qiang Xu, Qianming Du, Wen Lv, Yang Sun
This study identifies SHP2-driven endothelial activation as a key driver of estradiol-independent endometrial sterile inflammation and shows that targeting SHP2 can alleviate endometrial hyperplasia in mice.
bioRxiv · Jan 16, 2024 · PreprintMolecular Biology