Minjia Tan

Deconvolution of multiplexed peptidoform mass spectra enables high-resolution profiling of complex protein modification patterns

The paper introduces PTMdecoder, a tool for deconvoluting multiplexed mass spectra to identify and quantify isobaric modification peptidoforms with high sensitivity and accuracy.

Visible-Light-Controlled Residue-Selective Cross-Linking for Deciphering Protein Complexes and Dynamic Protein-Protein Interactions in Live Cells

This paper introduces a visible-light-controlled cross-linking method for analyzing protein complexes and dynamic interactions in live cells, showing improved accuracy and temporal control.

SHP2-triggered endothelium activation fuels estradiol-independent endometrial sterile inflammation

This study identifies SHP2-driven endothelial activation as a key driver of estradiol-independent endometrial sterile inflammation and shows that targeting SHP2 can alleviate endometrial hyperplasia in mice.

Quartet protein reference materials and datasets for multi-platform assessment of label-free proteomics

The paper develops Quartet, a proteome reference material with built-in truths, to assess label-free proteomics reproducibility across platforms and labs.