FlexiTAC enables controllable PROTAC linker generation across diverse structural settings using a Bayesian flow network with posterior guidance
Yuzhang Li, Yupu Zhao, Lixin Zhou, Changying Huang, Qisheng Xu, Yang Chen, Qin Zheng, Kelong Fan, Jing Yang, Duanhua Cao
FlexiTAC generates controllable PROTAC linkers using a Bayesian flow network, improving validity and pose quality over existing methods.
bioRxiv · Aug 30, 2026 · PreprintBioinformatics