Yuzhang Li

OmniSyn unifies target-aware molecular generation and optimization within a synthesis-native LLM framework across the human proteome

OmniSyn generates and optimizes target-specific molecules with synthesis traces using a sequence-conditioned LLM, achieving state-of-the-art performance on drug discovery benchmarks.

FlexiTAC enables controllable PROTAC linker generation across diverse structural settings using a Bayesian flow network with posterior guidance

FlexiTAC generates controllable PROTAC linkers using a Bayesian flow network, improving validity and pose quality over existing methods.