Qin Zheng

OmniSyn unifies target-aware molecular generation and optimization within a synthesis-native LLM framework across the human proteome

OmniSyn generates and optimizes target-specific molecules with synthesis traces using a sequence-conditioned LLM, achieving state-of-the-art performance on drug discovery benchmarks.

FlexiTAC enables controllable PROTAC linker generation across diverse structural settings using a Bayesian flow network with posterior guidance

FlexiTAC generates controllable PROTAC linkers using a Bayesian flow network, improving validity and pose quality over existing methods.

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells

This study shows that IgG in fibromyalgia syndrome activates mast cells via Mrgprb2, leading to hypersensitivity and inflammation.