A systemic circadian nicotinic acid riboside (NaR) signal engages the unfolded protein response and adipogenesis via the prefoldin complex
Ivan Vlassakev, Christina Savva, Liying Zhou, Danilo Ritz, Alexander Schmidt, Cholsoon Jang, Amir Ata Saei, Paul Petrus
This paper identifies NaR as a liver clock-controlled metabolite that links circadian rhythms to adipogenesis via the prefoldin complex and UPR signaling.
bioRxiv · Mar 6, 2026 · PreprintSystems Biology