Cholsoon Jang

This study identifies PDK4 as a regulator of TGF{beta}-mediated SMC contractility, showing that reducing PDK4 limits atherosclerosis by preserving SMC phenotype.

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

This paper identifies NaR as a liver clock-controlled metabolite that links circadian rhythms to adipogenesis via the prefoldin complex and UPR signaling.

This paper shows that spinal cord oligodendrocyte metabolic changes after injury lead to β-amyloid production and chronic pain.

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

This study shows that a low protein diet enhances metabolic health and weight loss in mice after sleeve gastrectomy, challenging current high-protein dietary recommendations.

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.

This study identifies mevalonate biosynthesis as a therapeutic target and biomarker for gemcitabine-resistant pancreatic cancer.

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

The paper shows that metabolic reprogramming in the spinal cord, driven by injury, leads to chronic pain by suppressing autophagy and nutrient availability, and that dietary intervention can prevent this transition.

This study shows that blocking intestinal fructose catabolism reduces obesity and insulin resistance by decreasing fat absorption and altering gut microbiome and immune interactions.

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

This study measures cardiac metabolite exchange in pigs during myocardial ischemia and reperfusion, revealing dynamic metabolic changes and transient protein degradation.

This study identifies how cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to promote fatty acid oxidation over glucose.

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

This study identifies sex-dependent metabolic differences in kidneys using arteriovenous metabolomics and transcriptomics, revealing distinct metabolic responses to a ketogenic diet.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

This study identifies TDP-43 dysfunction and reduced m6A modification as mechanisms causing aberrant splicing in Huntington's disease using mouse and human brain data.

The paper quantifies nutrient preferences of gut bacteria in mice using isotope tracing and finds dietary fiber, protein, and host-derived metabolites drive microbial growth.

The paper uses proteomics to show that β-hydroxybutyrylation of proteins in mouse liver under ketogenic conditions affects metabolic pathways and enzyme function.

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.