Danilo Ritz

This study identifies ARF-1 as a regulator of cargo sorting at FERARI-dependent endosomal recycling hubs through its cycling between active and inactive states.

This study uses CoPISA and proteomics to analyze venetoclax-azacitidine response in AML cells, identifying adaptive vulnerabilities like NRP2.

This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.

This paper identifies a stage-specific proteomic signature of Alzheimer's disease using plasma proteomics and finds a proteomic switch associated with disease progression.

The paper identifies ATP13A3 as a plasma membrane polyamine transporter regulated by antizyme, showing that polyamine elevation leads to transporter internalization and reduced uptake.

This study shows Arf1 regulates TORC1 activity in yeast by both inhibiting and promoting its function under different stress conditions.

This study provides a molecular and structural map of the ciliary base in mammalian multiciliated cells using advanced imaging and molecular techniques.

This paper introduces CoPISA, a proteomics workflow that identifies combination-specific protein targets in AML, revealing conjunctional targeting mechanisms beyond classical drug synergy.

CoPISA provides a proteomics dataset profiling protein solubility and stability responses to single and combined drug treatments in AML cell lines, enabling analysis of combinatorial drug effects.

This paper identifies NaR as a liver clock-controlled metabolite that links circadian rhythms to adipogenesis via the prefoldin complex and UPR signaling.

This study identifies DRP1 and Ca2+ as essential for endocytic lysosome reformation by mediating tubule fission at ER-mitochondria-endolysosome contact sites.

This study investigates how exercise induces molecular and signaling changes in the spinal cord using multi-omic approaches, revealing coordinated neuron-glia communication as key to spinal cord adaptation.

The paper shows that bacterial-derived RNA extends healthspan in C. elegans by reducing protein aggregation through inter-tissue communication and systemic RNAi.

The paper identifies 51 protein targets modified by polyamines through transglutaminase 2, with modifications occurring on 66 sites, many involved in translation, cytoskeletal organization, or cancer.

The paper investigates how gene regulatory dynamics integrate lineage-specific inputs to drive skeletogenic cell fate convergence in vertebrates.

This study identifies xenorceptides, a new class of antibiotics that target BamA in Gram-negative bacteria, showing potent activity and limited resistance.

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

The paper shows that TORC1 inhibits Stm1 to reactivate dormant ribosomes, revealing an evolutionarily conserved mechanism for ribosome preservation.

This study identifies transcription factor networks involved in hepatocyte lipotoxicity using integrative transcriptomic, proteomic, and chromatin accessibility analyses, showing that MAFK and TCF4 deletion protects against fatty acid toxicity.

This study reveals that RNA-bound PGC-1α forms liquid-like nuclear condensates to regulate gene expression and transcriptional networks in response to metabolic stimuli.