Senescent cell clearance ameliorates temporal lobe epilepsy and associated spatial memory deficits in mice
Tahiyana Khan, David J. McFall, Abbas I. Hussain, Logan A. Frayser, Timothy P. Casilli, Meaghan C. Steck, Irene Sánchez-Brualla, Noah M. Kuehn, Michelle Cho, Jacqueline A. Barnes, Brent T. Harris, Stefano Vicini, Patrick Alexander Forcelli
This study shows that clearing senescent cells reduces seizures and improves memory in a mouse model of temporal lobe epilepsy and finds similar SC accumulation in human TLE patients.
Annals of Neurology · Dec 22, 2025Peer-reviewedNeuroscience