Brent T. Harris

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis.

This paper evaluates combining expression-based surrogate variables and genotype-based principal components in differential expression analysis, finding the combined approach improves replicability and biological recall in ALS datasets.

Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer

The paper identifies periductal fibroblast density as a key factor in immune exclusion in pancreatic cancer, showing that CD44-dependent stromal checkpoints restrict leukocyte access to tumor epithelium.

Senescent cell clearance ameliorates temporal lobe epilepsy and associated spatial memory deficits in mice

This study shows that clearing senescent cells reduces seizures and improves memory in a mouse model of temporal lobe epilepsy and finds similar SC accumulation in human TLE patients.

Glutamate-Handling Proteins Associate with Adverse Clinicopathologic Features and Comorbidities in Invasive Lobular Carcinoma

The paper examines glutamate-handling proteins in ILC and finds associations with tumor size, ER expression, and comorbidities, suggesting therapeutic targets.

Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila

The paper investigates mitochondrial distribution changes in Drosophila neurodegeneration, finding altered mitochondrial localization at the axon initial segment associated with reduced Cdk5 activity.

MANIPULATING MITOCHONDRIAL REACTIVE OXYGEN SPECIES ALTERS SURVIVAL IN UNEXPECTED WAYS IN A DROSOPHILA MODEL OF NEURODEGENERATION

This study manipulates mitochondrial reactive oxygen species in a Drosophila neurodegeneration model and finds that increased H2O2 correlates with improved survival, while drug effects depend on treatment timing, duration, and genotype.

Cell environment shapes TDP-43 function: implications in neuronal and muscle disease

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals disorder-specific expression changes in major psychiatric disorders

The paper uses deep RNA sequencing to compare gene expression in the subgenual anterior cingulate cortex across major psychiatric disorders and controls, finding disorder-specific expression changes and genetic associations.

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

The paper uses unsupervised machine learning to identify three molecular subtypes in ALS cortex samples, associated with oxidative stress, retrotransposon activation, and glial activation.