Patrick Alexander Forcelli

This study develops a mouse model of brainstem cholinergic cell loss to show delayed motor impairments and circuit reorganization in Parkinson's disease.

This study shows that clearing senescent cells reduces seizures and improves memory in a mouse model of temporal lobe epilepsy and finds similar SC accumulation in human TLE patients.

This study uses optogenetics to show that dorsal striatal activation suppresses seizures while silencing increases seizure activity in different epilepsy models.

This study shows that parvalbumin basket cells are less active during SWRs in a mouse AD model, contributing to memory impairment.