A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis
Joji Nakayama, Lora Tan, Yan Li, Boon Cher Goh, Shu Wang, Hideki Makinoshima, Zhiyuan Gong
The paper identifies Pizotifen as an anti-metastasis drug by screening chemicals that disrupt zebrafish gastrulation and show it suppresses EMT-mediated metastasis through HTR2C inhibition.
eLife · Dec 17, 2021Peer-reviewedDevelopmental Biology