Evolutionary BiologybioRxivPreprint
Differences between the de novo proteome and its non-functional precursor can result from neutral constraints on its birth process, not necessarily from natural selection alone
Lou Nielly-Thibault, Christian R Landry
The paper shows that properties of novel functional proteins depend on variance and correlation of junk polypeptides, not just natural selection, and predicts effects of GC content on protein length and disorder.
DOI 10.1101/289330