Intrinsically disordered N-terminal and structured DNA-binding domains jointly regulate progesterone receptor transcriptional condensates
Louna Raluy, Dominik Saul, Catalina Romero-Aristizabal, Borja Requena, Lara de Llobet, Robyn Laura Kosinsky, Nadine Youssef, Carla Garcia‐Cabau, Maciej Lewenstein, Xavier Salvatella, Gorka Muñoz-Gil, M.F. Garcia Parajo, Juan Andres Torreno-Pina, Priyanka Sharma
This study shows that both intrinsically disordered and structured domains of the Progesterone Receptor are required for transcriptional condensate formation and regulate distinct gene expression programs.
bioRxiv · Apr 23, 2026 · PreprintBiophysics