Xavier Salvatella

This study shows that both intrinsically disordered and structured domains of the Progesterone Receptor are required for transcriptional condensate formation and regulate distinct gene expression programs.

The paper shows a small molecule selectively targets an oligomeric form of a protein with an intrinsically disordered region, altering its interaction network and condensation properties.

This study investigates how small molecules stabilize oligomers of the androgen receptor activation domain using molecular dynamics simulations and NMR spectroscopy, revealing mechanisms that inform inhibitor design.

This study investigates Thio-2's mechanism of action in inhibiting AR signaling in CRPC, showing it acts independently of BAG-1 isoforms and with potential AR NTD binding.