Lara de Llobet

This study shows that both intrinsically disordered and structured domains of the Progesterone Receptor are required for transcriptional condensate formation and regulate distinct gene expression programs.

The paper shows TFIIIC binding to Alu elements regulates gene expression through chromatin looping and histone acetylation during serum starvation.

The paper identifies Hormone-Control Regions (HCRs) that organize genome structure and mediate opposing transcriptional responses to steroid hormones in breast cancer cells.

The paper shows that the unliganded progesterone receptor (PR) maintains ESR1 expression and DNA methylation in hormone-deprived breast cancer cells, and that PR depletion leads to increased promoter methylation and reduced ESR1 expression.