Dominik Saul

IL-17A potentiates malignant T-cell viability via electron transport chain complex I in cutaneous T-cell lymphoma

This study identifies IL-17A's role in enhancing T-cell viability through mitochondrial complex I in CTCL, suggesting therapeutic targeting of this pathway.

SenoQuant: One-stop AI software for senescence marker analysis and prediction

SenoQuant is an AI software for analyzing and predicting senescence markers in tissues, offering spatial quantification across imaging modalities and supporting custom models.

Intrinsically disordered N-terminal and structured DNA-binding domains jointly regulate progesterone receptor transcriptional condensates

This study shows that both intrinsically disordered and structured domains of the Progesterone Receptor are required for transcriptional condensate formation and regulate distinct gene expression programs.

Epigenetic Context Defines the Transcriptional Activity of Canonical and Noncanonical NF-κB Signaling in Pancreatic Cancer

This study identifies TNF and TWEAK as activators of canonical and noncanonical NF-κB signaling in PDAC, revealing distinct epigenetic dependencies of RELA and RELB.

The Multifaceted Phenotype of Senescent HL-60/S4 Macrophages

The paper uses GSEA to analyze the transcriptome of HL-60/S4 macrophages, identifying senescence-related gene sets and phenotypic changes.